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Proceedings of The First International Conference on Systems Biology The 9th JST International Symposium
Vol. 1 (2000)

Opening Remarksi
Masahiro Kawasaki
公開日: 31-Oct-2001
[抄録] [Image PDF (62K)] 
List of Committee Membersiii
公開日: 31-Oct-2001
[Image PDF (21K)] 
Perspectives on Systems Biology1
Hiroaki Kitano
公開日: 31-Oct-2001
[抄録] [Image PDF (741K)] 
Plenary Invited Talk
Genome Project and the Future Medicine		21
Yusuke Nakamura
公開日: 31-Oct-2001
[抄録] [Image PDF (44K)] 

<Abstracts of Invited Speaker's and Peer Reviewed Papers>

Software Platform and Data Resources
The ERATO Systems Biology Workbench: an Integrated Environment for Multiscale & Multi-Theoretic Simulations of Molecular Biology25
Hamid Bolouri, Andrew Finney, Michael Hucka, Herbert Sauro, John Doyle and Hiroaki Kitano
公開日: 31-Oct-2001
[抄録] [Image PDF (51K)] 
E-CELL Project: Towards Whole Cell Simulation26
Masaru Tomita
公開日: 31-Oct-2001
[抄録] [Image PDF (43K)] 
Tools for Simulating Large Biological Systems-the Need for Optimization27
Pedro Mendes
公開日: 31-Oct-2001
[抄録] [Image PDF (48K)] 
Stochastic Modeling and Simulation of Cell Signaling Using StochSim28
Thomas Simon Shimizu
公開日: 31-Oct-2001
[抄録] [Image PDF (34K)] 
Towards a Virtual Biological Laboratory29
Jörg. Stelling, A. Kremling and E. D. Gilles
公開日: 31-Oct-2001
[抄録] [Image PDF (590K)] 

Reconstruction & Reverse Engineering of Genetic Network
Generative Model Based Analysis of Cancer Associated Gene Expression Matrices39
Mattias Wahde and Zoltan Szallasi
公開日: 31-Oct-2001
[抄録] [Image PDF (477K)] 
Inference of a Gene Regulatory Network Using Steady-State Expression Data46
Koji M. Kyoda, Mineo Morohashi and Shuichi Onami
公開日: 31-Oct-2001
[抄録] [Image PDF (53K)] 

System-Level Analysys
Modeling Intracellular Systems at Multiple Levels of Abstraction48
Adam P. Arkin
公開日: 31-Oct-2001
[抄録] [Image PDF (37K)] 
Bacterial Chemotaxis: Using Computer Models to Unravel Mechanism49
Dennis Bray
公開日: 31-Oct-2001
[抄録] [Image PDF (39K)] 
Robustness and Dynamics in Biological Networks50
John Doyle
公開日: 31-Oct-2001
[抄録] [Image PDF (71K)] 
Constructing Mathematical Models of Biological Signal Transduction Pathways52
Tau-Mu Yi
公開日: 31-Oct-2001
[抄録] [Image PDF (29K)] 
Combination of Biphasic Response Regulation and Positive Feedback as a General Regulatory Mechanism in Homeostasis and Signal Transduction53
Andre Levchenko, Jehoshua Bruck and Paul W. Sternberg
公開日: 31-Oct-2001
[抄録] [Image PDF (512K)] 
Automatic Model Generation for Signal Transduction with Applications to Map-Kinase Pathways64
Bruce E Shapiro, Andre Levchenko and Eric Mjolsness
公開日: 31-Oct-2001
[抄録] [Image PDF (550K)] 
Distinct Roles of Rho-Kinase Pathway and Myosin Light Chain Kinase Pathway in Phosphorylation of Myosin Light Chain: Kinetic Simulation Study75
Shinya Kuroda, Nicolas Schweighofer, Mutsuki Amano, Kozo Kaibuchi and Mitsuo Kawato
公開日: 31-Oct-2001
[抄録] [Image PDF (175K)] 
Virtual Patients and Virtual Drug Targets: A Systems-Level Approach to Pharmaceutical R&D81
Todd Dubnicoff, David Polidori, Alex Bangs and Tom Paterson
公開日: 31-Oct-2001
[抄録] [Image PDF (690K)] 
Strategic Approach to Determine the Yeast Genetic Regulatory Network with Microarray Data.95
Satoru Kuhara
公開日: 31-Oct-2001
[抄録] [Image PDF (39K)] 
Comprehensive Measurement of C. elegans Gene Expression96
Yuji Kohara
公開日: 31-Oct-2001
[抄録] [Image PDF (28K)] 
Systematic Isolation of Deletion Mutants to Analyze Neural Development in the Nematode Caenorhabditis elegans97
Shohei Mitani
公開日: 31-Oct-2001
[抄録] [Image PDF (45K)] 
Automatic Acquisition of Cell Lineage Through 4D Microscopy and Analysis of Early C. Elegans Embryogenesis98
Shuichi Onami
公開日: 31-Oct-2001
[抄録] [Image PDF (31K)] 
The Systeome Project99
Hiroaki Kitano
公開日: 31-Oct-2001
[抄録] [Image PDF (187K)] 

<Abstracts of Poster Presentation>
Knowledge Representation for Systems Biology107
Su-Shing Chen
公開日: 31-Oct-2001
[抄録] [Image PDF (351K)] 
SiliCell initiative: “In Silico Cell Simulation”. Modelisation and Simulation of Functional Pathways113
Pierre Mazière, Claude Granier, Isabelle Mougenot, Thérèse Libourel, Charles Auffray, Bernard Pau and Franck Molina
公開日: 31-Oct-2001
[抄録] [Image PDF (379K)] 
“Biobje” as a New Model System of Gene Expression119
Nobukazu Ohki and Masatoshi Hagiwara
公開日: 31-Oct-2001
[抄録] [Image PDF (267K)] 
BEST-KIT: Development of Biochemical Engineering System Analyzing Tool-KIT124
Kenji Sakuraba, Jun-ichi Ueno, Masakazu Mori, Kouji Tanaka, Jun Yoshimura and Masahiro Okamoto
公開日: 31-Oct-2001
[抄録] [Image PDF (446K)] 
Efficient Numerical Optimization Algorithm Based on Genetic Algorithm for Inverse Problem: System for the Inference of Genetic Networks130
Masahiro Okamoto, Daisuke Tominaga, Nobuto Koga and Yukihiro Maki
公開日: 31-Oct-2001
[抄録] [Image PDF (402K)] 
Finding Original Regulatory Networks with Weight Matrices136
Nobuhisa UEDA and Taisuke SATO
公開日: 31-Oct-2001
[抄録] [Image PDF (289K)] 
Different Characteristics of the Inbred FOK Rat in Addition to Genotypic Resistance Adaptation to a Severe Hot Environment142
F. Furuyama, A. Kuroshima, O. Shido, T. Yahata, E. Tanaka, A. Ikemoto, H. Okuyama and H. Nishino
公開日: 31-Oct-2001
[抄録] [Image PDF (281K)] 
Redox-Dependent Control Phenomena in Photosynthetic Bacteria148
H. Grammel, S. Klamt, R. Ghosh and E.D. Gilles
公開日: 31-Oct-2001
[抄録] [Image PDF (287K)] 
Spatial Sensing in Dictyostelium: Switching Behavior154
Pablo A. Iglesias and Andre Levchenko
公開日: 31-Oct-2001
[抄録] [Image PDF (181K)] 
System Estimation of Cell Dynamics Using E-CELL Simulation Environment160
Tomoharu Iwata, Kouichi Takahashi, Yusuke Saito and Masaru Tomita
公開日: 31-Oct-2001
[抄録] [Image PDF (78K)] 
The Large-Scale Organization of Metabolic Networks162
H. Jeong, B. Tombor, R. Albert, Z.N. Oltvai and A.-L. Barabásil
公開日: 31-Oct-2001
[抄録] [Image PDF (32K)] 
EXTENSION OF A MATHEMATICAL MODEL FOR CARBON CATABOLITE REPRESSION IN E. coli TO DESCRIBE GALACTOSE EFFLUX163
A. Kremling, K. Bettenbrock and E.D. Gilles
公開日: 31-Oct-2001
[抄録] [Image PDF (182K)] 
Complexity in Regulation Generates Robustness in Bacterial Molecular Networks167
Hiroyuki Kurata and Kazunari Taira
公開日: 31-Oct-2001
[抄録] [Image PDF (440K)] 
The Approach for Bacterial Phenotype Representation by Using Bacterial Whole Genomes173
Ken Kurokawa, Tatsuya Takagi and Teruo Yasunaga
公開日: 31-Oct-2001
[抄録] [Image PDF (269K)] 
Theoretical Study for Circadian Rhythm in Drosophila: Condition for Generating a Limit Cycle179
Gen Kurosawa, Atsushi Mochizuki and Yoh Iwasa
公開日: 31-Oct-2001
[抄録] [Image PDF (241K)] 
A New Method for Estimating Cell Lineage: Theory and Application185
Atsushi Mochizuki, Makoto Koga and Yasumi Ohshima
公開日: 31-Oct-2001
[抄録] [Image PDF (241K)] 
Identification of Structural Weaknesses in Biochemical Models through Parameter Sensitivity Analysis191
Mineo Morohashi, Mark Borisuk, Hamid Bolouri and Hiroaki Kitano
公開日: 31-Oct-2001
[抄録] [Image PDF (186K)] 
Theoretical Estimation of Systematic Errors Caused by Probe-Target Cross-Hybridization in DNA Microarray Experiments195
Mitsuteru Nakao, K.Yoshinori OKUJI, Masumi Itoh, Toshiaki Katayama, Shuichi Kawashima, Iwane Suzuki, Norio Murata and Minoru Kanehisa
公開日: 31-Oct-2001
[抄録] [Image PDF (261K)] 
Computer Simulation of Enzyme Deficiencies in Human Erythrocyte using the E-CELL Simulation System201
Yoichi Nakayama, Ayako Kinoshita, Ryo Matsushima and Masaru Tomita
公開日: 31-Oct-2001
[抄録] [Image PDF (52K)] 
Genesis of Genetic Codes and Other Semeiotic Systems by means of Neural-Network-like Hierarchical Sociogenesis and Bio-Machinogenesis203
Koji Ohnishi, Shouken Hokari and Daiji Kambe
公開日: 31-Oct-2001
[抄録] [Image PDF (295K)] 
Circulated Transport Phenomena Driven by the Interaction of Arterial and Venous Vessel Systems Simulated by Fractal Properties210
Masahiko Monma, Takeshi Saito, Yasuo Yonezawa and Takashi Igarashi
公開日: 31-Oct-2001
[抄録] [Image PDF (273K)] 
Pattern Formation on Skin of Tropical Fishes216
Hiroto Shoji, Atushi Mochizuki, Yoh Iwasa and Shigeru Kondo
公開日: 31-Oct-2001
[抄録] [Image PDF (302K)] 
Fine Structural Analysis of the Transcription Start Sites of Human mRNA222
Yutaka Suzuki, Hirotoshi Taira, Tatsuhiko Tsunoda, Junko Mizushima-Sugano, Jun Sese, Hiroko Hata, Toshio Ota, Takao Isogai, Yoshiyuki Sasaki, Toshihiro Tanaka, Yusuke Nakamura, Shinichi Morishita, Kousaku Okubo, Akira Suyama and Sumio Sugano
公開日: 31-Oct-2001
[抄録] [Image PDF (364K)] 
Development of the New Modular Simulation Engine for E-CELL Simulation Environment230
Kouichi Takahashi, Tomoharu Iwata, Masayuki Okayama, Motohiro Yoneda, Yusuke Saito, Tadashi Yanagihara and Masaru Tomita
公開日: 31-Oct-2001
[抄録] [Image PDF (78K)] 
Analysis of DNA Coding Regions233
Fumihiko Takeuchi, Kenji Yamamoto and Hiroshi Yoshikura
公開日: 31-Oct-2001
[抄録] [PDF (315K)] 
A Cell-Sorting Model Can Explain Cone Mosaic Pattern of Medaka239
Shusaku Tohya, Atsushi Mochizuki and Yoh Iwasa
公開日: 31-Oct-2001
[抄録] [Image PDF (284K)] 
Gene Expression Switch Model Based on Liquid Crystalling like Phenomena of Double Stranded DNA Chain245
Yasuo Yonezawa and Hidetoshi Kuramochi
公開日: 31-Oct-2001
[抄録] [Image PDF (224K)] 
Integrative Modeling of Mitochondrial Energy Metabolism251
Katsuyuki Yugi and Masaru Tomita
公開日: 31-Oct-2001
[抄録] [Image PDF (87K)] 

Speaker's Profile255
公開日: 31-Oct-2001
[Image PDF (396K)]