EXTENSION OF A MATHEMATICAL MODEL FOR CARBON CATABOLITE REPRESSION IN E. coli TO DESCRIBE GALACTOSE EFFLUX
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| A. Kremling1), K. Bettenbrock1) and E.D. Gilles1) |
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| 1) MPI für Dynamik komplexer technischer Systeme |
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| A mathematical model that is able to describe the phenomenon of glucose-lactose diauxie in E. coli was peviously presented [3]. Although the model reflects growth and gene induction of the wildtype strain and of some mutants very well it failed to describe the behavior of a ptsG mutant lacking the major uptake system for glucose. Experimental data showed that relatively high rates of efflux of glucose and galactose from the cells could account for the difference in model and reality. Here, we desribe the analysis of galactose export in E. coli and the extension of the model by inclusion of a galactose transport/export system. |
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