 | “Biobje” as a new model system of gene expression
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| | Nobukazu Ohki1) and Masatoshi Hagiwara1) |
| | 1) Department of Functional Genomics, Medical Research Institute, Tokyo Medical and Dental University |
| | The process of eukaryotic gene expression is a multi-step reaction system. Premature mRNAs produced at transcription sites are processed (capping, polyA addition and splicing), transport to ribosomes in the cytoplasm from the nucleus through nuclear pores, and translated to proteins. “Biobje” is a newly developed simulation model to analyze this complicated gene expression system in eukaryotic cells. In this paper Biobje is applied to circadian oscillation of Drosophila genes, and the model suggests that the stability of the mRNAs of per, tim, and cyc are crucial for the duration and robustness of the circadian rhythm. |
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