| | 主な研究成果 |  |
| (1)論文発表 | |
| ‹1996年› | |
| Okumura, E., Sekiai, T., Hisanaga, S., Tachibana, K., and Kishimoto, T. Initial triggering of M-phase in starfish oocytes: A possible novel component of MPF besides cdc2 kinase. J. Cell Biol. 132, 125-135 (1996). | |
| Honma, N., Uchida, A., Hirose, H., Srsen, V., Kishimoto, T., and Hisanaga, S. Two types of apoptotic cell death of rat central nervous system-derived neuroblastoma B50 and B104 cells: apoptosis induced during proliferation and after differentiation. J. Neurochem. 67, 1856-1865 (1996). | |
| Uchida, K., Muramatsu, T., Tachibana, K., Kishimoto, T., and Furuya, M. Isolation and characterization of the cDNA for an A-like cyclin in Adiantum capillus-veneris L. Plant Cell Physiol. 37, 825-832 (1996). | |
| Kishimoto, T. Starfish maturation-promoting factor. Trends Biochem. Sci. 21, 35-37 (1996). | |
| Kozasa, T., Kaziro, Y., Ohtsuka, T., Grigg, J.J., Nakajima, S., and Nakajima, Y. G protein specificity of the muscarine-induced increase in an inward rectifier potassium current in AtT-20 cells. Neurosci. Res. 26, 289-297 (1996). | |
| Miyake, M., Mizutani, S., Koide, H., and Kaziro, Y. Unfarnesylated transforming Ras mutant inhibits the Ras-signaling pathway by forming a stable Ras.Raf complex in the cytosol. FEBS Lett. 378, 15-18 (1996). | |
| Ohtsuka, T., Kaziro, Y., and Satoh, T. Analysis of the T-cell activation signaling pathway mediated by tyrosine kinases, protein kinase C, and Ras protein, which is modulated by intracellular cyclic AMP. Biochim. Biophys. Acta 1310, 223-232 (1996). | |
| Satoh, T., Kato, J., Nishida, K., and Kaziro, Y. Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation. FEBS Lett. 386, 230-234 (1996). | |
| ‹1997年› | |
| Tachibana, K., Machida, T., Nomura, Y., and Kishimoto, T. MAP kinase links the fertilization signal transduction pathway to the G1/S-phase transition in starfish eggs. EMBO J. 16, 4333-4339 (1997). | |
| Ando, S., Ikuhara, T., Kamata, T., Sasaki, Y., Hisanaga, S., Kishimoto, T., Ito, H., and Inagaki, M. Role of the pyrrolidine ring of proline in determining the substrate specificity of cdc2 kinase or cdk5. J. Biochem. 122, 409-414 (1997). | |
| Honma, N., Hosono, Y., Kishimoto, T., and Hisanaga, S. Phosphorylation of retinoblastoma protein at apoptotic cell death in rat neuroblastoma B50 cells. Neurosci. Lett. 235, 45-48 (1997). | |
| Itoh, T. J., Hisanaga, S., Hosoi, T., Kishimoto, T., and Hotani, H. Phosphorylation states of microtubule-associated protein 2 (MAP2) determine the regulatory role of MAP2 in microtubule dynamics. Biochemistry 36, 12574-12582 (1997). | |
| Ookata, K., Hisanaga, S., Sugita, M., Okuyama, A., Murofushi, H., Kitazawa, H., Chari, S., Bulinski, J. C., and Kishimoto, T. MAP4 is the in vivo substrate for cdc2 kinase in HeLa cells--- Identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4---. Biochemistry 36, 15873-15883 (1997). | |
| Kishimoto, T., and Okumura, E. In vivo Regulation of the entry into M-phase: initial activation and nuclear translocation of cyclin B/Cdc2. in Progress in Cell Cycle Res. (Meijer, L., Guidet, S., and Philippe, M. eds.), vol. 3, pp.241-249, Plenum Press, New York (1997). | |
| Edamatsu, H., Kaziro, Y., and Itoh, H. Inducible high-level expression vector for mammalian cells, pEF-LAC carrying human elongation factor 1α promoter and lac operator. Gene 187, 289-294 (1997). | |
| Hirasawa, A., Sugawara, T., Awaji, T., Tsumaya, K., Itoh, H., and Tsujimoto, G. Subtype-specific differences in subcellular localization of α1-adrenoceptors: chlorethylclonidine preferentially alkylates the accessible cell surface α1-adrenoceptors irrespective of the subtype. Mol. Pharmacol. 52, 764-770 (1997). | |
| Nishiya, T., Uehara, T., Edamatsu, H., Kaziro, Y., Itoh, H., and Nomura, Y. Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-γ-induced MAPK activation that is mediated by p21ras. FEBS Lett. 408, 33-38 (1997). | |
| Suzuki, J., Kaziro, Y., and Koide, H. An activated mutant of R-Ras inhibits cell death caused by cytokine deprivation in BaF3 cells in the presence of IGF-I. Oncogene 15, 1689-1697 (1997). | |
| Terada, K., Kaziro, Y., and Satoh, T. Ras-dependent activation of c-Jun N-terminal kinase/stress-activated protein kinase in response to interleukin-3 stimulation in hematopoietic BaF3 cells. J. Biol. Chem. 272, 4544-4548 (1997). | |
| Tomura, H., Itoh, H., Sho, K., Sato, K., Nagao, M., Ui, M., Kondo,Y., and Okajima, F. βγ subunits of pertussis toxin-sensitive G proteins mediate A1 adenosine receptor agonist-induced activation of phospholipase C in collaboration with thyrotropin. A novel stimulatory mechanism through the cross-talk of two types of receptors. J. Biol. Chem. 272, 23130-23137 (1997). | |
| Umemori, H., Inoue, T., Kume, S., Sekiyama, N., Nagao, M., Itoh, H., Nakanishi, S., Mikoshiba, K., and Yamamoto, T. Activation of the G protein Gq/11 through tyrosine phosphorylation of the α subunit. Science 276, 1878-1881 (1997). | |
| Yamauchi, J., Kaziro, Y., and Itoh, H. C-terminal mutation of G protein β subunit affects differentially extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways in human embryonal kidney 293 cells. J. Biol. Chem. 272, 7602-7607 (1997). | |
| Yamauchi, J., Nagao, M., Kaziro, Y., and Itoh, H. Activation of p38 mitogen-activated protein kinase by signaling through G protein-coupled receptors. Involvement of Gβγ and Gαq/11 subunits. J. Biol. Chem. 272, 27771-27777 (1997). | |
| ‹1998年› | |
| Okano-Uchida, T., Sekiai, T., Lee, K., Okumura, E., Tachibana, K., and Kishimoto, T. In vivo Regulation of cyclin A/Cdc2 and cyclin B/Cdc2 through meiotic and early cleavage cycles in starfish. Dev. Biol. 197, 39-53 (1998). | |
| Shimada, A., Ohsumi, K., and Kishimoto, T. An indirect role for cyclin B-Cdc2 in inducing chromosome condensation in Xenopus egg extracts. Biol. Cell. 90, 519-530 (1998). | |
| Wada, Y., Ishiguro, K., Itoh, T.J., Uchida, T., Hotani, H., Saito, T., Kishimoto, T., and Hisanaga, S. Microtubule-stimulated phosphorylation of tau at Ser202 and Thr205 by cdk5 decreases its microtubule nucleation activity. J. Biochem. 124, 738-746 (1998). | |
| Saito, T., Ishiguro, K., Onuki, R., Nagai, Y., Kishimoto, T., and Hisanaga, S. Okadaic acid-stimulated degradation of p35, an activator of CDK5, by proteasome in cultured neurons. Biochem. Biophys. Res. Commun. 252, 775-778 (1998). | |
| Kishimoto, T. Cell cycle arrest and release in starfish oocytes and eggs. Seminars Cell Dev. Biol. 9, 549-557 (1998). | |
| Deng, J., Kawakami, Y., Hartman, S.E., Satoh, T., and Kawakami, T. Involvement of Ras in Bruton’s tyrosine kinase-mediated JNK activation. J. Biol. Chem. 273, 16787-16791 (1998). | |
| Edamatsu, H., Kaziro, Y., and Itoh, H. Expression of an oncogenic mutant Gαi2 activates Ras in Rat-1 fibroblast cells. FEBS Lett. 440, 231-234 (1998). | |
| Mitamura, S., Ikawa, H., Mizuno, N., Kaziro, Y., and Itoh, H. Cytosolic nuclease activated by caspase-3 and inhibited by DFF-45. Biochem. Biophys. Res. Commun. 243, 480-484 (1998). | |
| Mizutani, S., Koide, H., and Kaziro, Y. Isolation of a new protein factor required for activation of Raf-1 by Ha-Ras: partial purification from rat brain cytosols. Oncogene 16, 2781-2786 (1998). | |
| Nagao, M., Yamauchi, J., Kaziro, Y., and Itoh, H. Involvement of protein kinase C and Src family tyrosine kinase in Gαq/11-induced activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. J. Biol. Chem. 273, 22892-22898 (1998). | |
| Suzuki, J., Kaziro, Y., and Koide, H. Synergistic action of R-Ras and IGF-1 on Bcl-xL expression and caspase-3 inhibition in BaF3 cells: R-Ras and IGF-1 control distinct anti-apoptotic kinase pathways. FEBS Lett. 437, 112-116 (1998). | |
| Tago, K., Kaziro, Y., and Satoh, T. Functional involvement of mSos in interleukin-3 and thrombin stimulation of the Ras, mitogen-activated protein kinase pathway in BaF3 murine hematopoietic cells. J. Biochem. 123, 659-667 (1998). | |
| Tanaka, T., Kohno, T., Kinoshita, S., Mukai, H., Itoh, H., Ohya, M., Miyazawa, T., Higashijima, T., and Wakamatsu, K. α helix content of G protein α subunit is decreased upon activation by receptor mimetics. J. Biol. Chem. 273, 3247-3252 (1998). | |
| ‹1999年› | |
| Uchida, A., Yorifuji, H., Lee, V.M.Y., Kishimoto, T., and Hisanaga, S. Neurofilaments of aged rats: The strengthened interneurofilament interaction and the reduced amount of NF-M. J. Neurosci. Res. 58, 337-348 (1999). | |
| Srsen, V., Kitazawa, H., Sugita, M., Murofushi, H., Bulinski, J.C., Kishimoto, T., and Hisanaga, S. Serum-dependent phosphorylation of human MAP4 at ser696 in cultured mammalian cells. Cell Struc. Funct. 24, 321-327 (1999). | |
| Kishimoto, T. Activation of MPF at meiosis reinitiation in starfish oocytes. Dev. Biol. 214, 1-8 (1999). | |
| Kishimoto, T. Oocyte maturation and spawning in starfish. in Encyclopedia of Reproduction (Knobil, E. and Neill, J.D. eds.), vol.3, pp.481-488, Academic Press, San Diego (1999). | |
| Hirabayashi, T., Kume, K., Hirose, K., Yokomizo, T., Iino, M., Itoh, H., and Shimizu, T. Critical duration of intracellular Ca2+ response required for continuous translocation and activation of cytosolic phospholipase A2. J. Biol. Chem. 274, 5163-5169 (1999). | |
| Kawano, T., Chen, L., Watanabe, S.Y., Yamauchi, J., Kaziro, Y., Nakajima, Y., Nakajima, S., and Itoh, H. Importance of the G protein γ subunit in activating G protein-coupled inward rectifier K+ channels. FEBS Lett. 463, 355-359 (1999). | |
| Kiyono, M., Satoh, T., and Kaziro, Y. G protein βγ subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25Mm. Proc. Natl. Acad. Sci. USA 96, 4826-4831 (1999). | |
| Nagao, M., Kaziro, Y., and Itoh, H. The Src family tyrosine kinase is involved in Rho-dependent activation of c-Jun N-terminal kinase by Gα12. Oncogene 18, 4425-4434 (1999). | |
| Nishida, K., Kaziro, Y., and Satoh, T. Anti-apoptotic function of Rac in hematopoietic cells. Oncogene 18, 407-415 (1999). | |
| Nishida, K., Kaziro, Y., and Satoh, T. Association of the proto-oncogene product Dbl with G protein βγ subunits. FEBS Lett. 459, 186-190 (1999). | |
| Sun, Y., Yamauchi, J., Kaziro, Y., and Itoh, H. Activation of c-fos promoter by Gβγ-mediated signaling: involvement of Rho and c-Jun N-terminal kinase. J. Biochem. 125, 515-521 (1999). | |
| Ueda, H., Yamauchi, J., Itoh, H., Morishita, R., Kaziro, Y., Kato, K., and Asano, T. Phosphorylation of F-actin-associating G protein γ12 subunit enhances fibroblast motility. J. Biol. Chem. 274, 12124-12128 (1999). | |
| Watanabe, S.Y., Albsoul-Younes, A.M., Kawano, T., Itoh, H., Kaziro, Y., Nakajima, S., and Nakajima, Y. Calcium phosphate-mediated transfection of primary cultured brain neurons using GFP expression as a marker: application for single neuron electrophysiology. Neurosci. Res. 33, 71-78 (1999). | |
| Yamauchi, J., Kaziro, Y., and Itoh, H. Differential regulation of mitogen-activated protein kinase kinase 4 (MKK4) and 7 (MKK7) by signaling from G protein βγ subunit in human embryonal kidney 293 cells. J. Biol. Chem. 274, 1957-1965 (1999). | |
| ‹2000年› | |
| Kitazawa, H., Iida, J., Uchida, A., Haino-Fukushima, K., Itoh, T.J., Hotani, H., Ookata, K., Murofushi, H., Bulinski, J.C., Kishimoto, T., and Hisanaga, S. Ser787 in the proline-rich region of human MAP4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization. Cell Struc. Funct. 25, 33-39 (2000). | |
| Tokuoka, H., Saito, T., Yorifuji, H., Wei, F-Y., Kishimoto, T., and Hisanaga, S. Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary cultures of embryo rat cortical neurons. J. Cell Sci. 113, 1059-1068 (2000). | |
| Kusakawa, G., Saito, T., Onuki, R., Ishiguro, K., Kishimoto, T., and Hisanaga, S. Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. J. Biol. Chem. 275, 17166-17172 (2000). | |
| Kawahara, H., Kasahara, M., Nishiyama, A., Ohsumi, K., Goto, T., Kishimoto, T., Saeki, Y., Yokosawa, H., Shimbara, N., Murata, S., Chiba, T., Suzuki, K., and Tanaka, T. Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes. EMBO J. 19, 4144-4153 (2000). | |
| Iwabuchi, M., Ohsumi, K., Yamamoto, T.M., Sawada, W., and Kishimoto, T. Residual Cdc2 activity remaining at meiosis I exit is essential for meiotic M-M transition in Xenopus oocyte extracts. EMBO J. 19, 4513-4523 (2000). | |
| Nishiyama, A., Tachibana, K., Igarashi, Y., Yasuda, H., Tanahashi, N., Tanaka, K., Ohsumi, K., and Kishimoto, T. A non-proteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M-phase. Genes Dev. 14, 2344-2357 (2000). | |
| Tachibana, K., Tanaka, D., Isobe, T., and Kishimoto, T. c-Mos forces the mitotic cell cycle to undergo meiosis II to produce haploid gametes. Proc. Natl. Acad. Sci. USA. 97, 14301-14306 (2000). | |
| Kishimoto, T. Meiotic cell-cycle control. Human Frontier Science Program Workshop IX “Cell Division and the Replicon“ (Fangman, W.L., Kishimoto, T., Kohiyama, M., and Coath, C. eds), pp.140-145. Human Frontier Science Program, Strasbourg (2000). | |
| Edamatsu, H., Kaziro, Y., and Itoh, H. LUCA15, a putative tumour suppressor gene encoding an RNA-binding nuclear protein, is down-regulated in ras-transformed Rat-1 cells. Genes Cells 5, 849-858 (2000). | |
| Inouye, K., Mizutani, S., Koide, H., and Kaziro, Y. Formation of the Ras dimer is essential for Raf-1 activation. J. Biol. Chem. 275, 3737-3740 (2000). | |
| Kato, J., Kaziro, Y., and Satoh, T. Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation. Biochem. Biophys. Res. Commun. 268, 141-147 (2000). | |
| Kawano, Y., Okamoto, I., Murakami, D., Itoh, H., Yoshida, M., Ueda, S., and Saya, H. Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the Rho family of small G proteins. J. Biol. Chem. 275, 29628-29635 (2000). | |
| Kawashima, T., Hirose, K., Satoh, T., Kaneko, A., Ikeda, Y., Kaziro, Y., Nosaka, T., and Kitamura, T. MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. Blood 96, 2116-2124 (2000). | |
| Kiyono, M., Kato, J., Kataoka, T., Kaziro, Y., and Satoh, T. Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25Mm upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1. J. Biol. Chem. 275, 29788-29793 (2000). | |
| Kiyono, M., Kaziro, Y., and Satoh T. Induction of Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25Mm following phosphorylation by the nonreceptor tyrosine kinase Src. J. Biol. Chem. 275, 5441-5446 (2000). | |
| Nagao, M., Kaziro, Y., and Itoh, H. Thrombin-induced inhibition of myoblast differentiation is mediated by Gβγ. FEBS Lett. 472, 297-301 (2000). | |
| Nakano, K., Yamauchi, J., Nakagawa, K., Itoh, H., and Kitamura, N. NESK, a member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and is expressed during the late stages of embryogenesis. J. Biol. Chem. 275, 20533-20539 (2000). | |
| Suzuki, J., Kaziro, Y., and Koide, H. Positive regulation of skeletal myogenesis by R-Ras. Oncogene 19, 1138-1146 (2000). | |
| Suzuki, J., Yamazaki, Y., Guang, L., Kaziro, Y., and Koide, H. Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts. Mol. Cell. Biol. 20, 4658-4665 (2000). | |
| Terada, K., Kaziro, Y., and Satoh, T. Analysis of Ras-dependent signals that prevent caspase-3 activation and apoptosis induced by cytokine deprivation in hematopoietic cells. Biochem. Biophys. Res. Commun. 267, 449-455 (2000). | |
| Ueda, H., Itoh, H., Yamauchi, J., Morishita, R., Kaziro, Y., Kato, K., and Asano, T. G protein βγ subunits induce stress fiber formation and focal adhesion assembly in a Rho-dependent manner in HeLa cells. J. Biol. Chem. 275, 2098-2102 (2000). | |
| Yamaguchi, T., Nagahama, M., Itoh, H., Hatsuzawa, K., Tani, K., and Tagaya, M. Regulation of the Golgi structure by the α-subunits of heterotrimeric G proteins. FEBS Lett. 470, 25-28 (2000). | |
| Yamauchi, J., Kawano, T., Nagao, M., Kaziro, Y., and Itoh, H. Gi-dependent activation of c-Jun N-terminal kinase in human embryonal kidney 293 cells. J. Biol. Chem. 275, 7633-7640 (2000). | |
| ‹2001年› | |
| Misaki, K., Mukai, H., Yoshinaga, C., Oishi, K., Isagawa, T., Takahashi, M., Ohsumi, K., Kishimoto, T., and Ono, Y. PKN delays mitotic timing by inhibition of Cdc25C: Possible involvement of PKN in the regulation of cell division. Proc. Natl. Acad. Sci. USA. 98, 125-129 (2001). | |
| Taniguchi, S., Fujita, Y., Takahashi, H., Hayashi, S., Kakita, A., Murayama, S., Saido, T., Hisanaga, S., Iwatsubo, T., and Hasegawa, M. Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains. FEBS Lett. 489, 46-50 (2001). | |
| Uchida, A., Tashiro, T., Komiya, Y., Yorifuji, H., Kishimoto, T., Nabeshima, Y., and Hisanaga, S. Neurofilaments of Klotho, the mutant mouse prematurely displaying symptoms resembling human aging. J. Neurosci. Res. 64, 364-370 (2001). | |
| Gotoh, T., Ohsumi, K., Matsui, T., Takisawa, H., and Kishimoto, T. Inactivation of the checkpoint kinase Cds1 is dependent on cyclin B-Cdc2 kinase activation at the meiotic G2/M-phase transition in Xenopus oocytes. J. Cell Sci. 114, 3397-3406 (2001). | |
| Chang, W., Gruber, D., Chari,S., Kitazawa, H., Hamazumi, Y., Hisanaga, S., and Bulinski, J. C. Phosphorylation of MAP4 affects microtubule properties and cell cycle progression. J. Cell Sci. 114, 2879-2887 (2001). | |
| Bibb, J.A., Nishi, A., O’Callaghan, J.P., Ule, J., Lan, M., Snyder, G.L., Horiuchi, A., Saito, T., Hisanaga, S., Czernik,j A.J., Nairn, A.C., and Greengard, P. Phosphorylation of protein phosphatase inhibitore-I by Cdk5. J. Biol. Chem. 276, 14490-14497 (2001). | |
| Ueda, H., Morishita, R., Yamauchi, J., Itoh, H., Kato, K., and Asano, T. Regulation of Rac and Cdc42 pathways by Gi during lysophosphatidic acid-induced cell spreading. J. Biol. Chem. 276, 6846-6852 (2001). | |
| Yamauchi, J., Itoh, H., Shinoura, H., Miyamoto, Y., Hirasawa, A., Kaziro, Y., and Tsujimoto, G. Involvement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase in a1B-adrenergic receptor/Gaq-induced inhibition of cell proliferation. Biochem. Biophys. Res. Commun. 281, 1019-1023 (2001). | |
| Yamazaki, Y., Kaziro, Y., and Koide, H. Ral promotes anchorage-independent growth of a human fibrosarcoma, HT1080. Biochem. Biophys. Res. Commun. 280, 868-873 (2001). | |
| Kato-Stankiewicz, J., Ueda, S., Kataoka, T., Kaziro, Y., and Satoh, T. Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner. Biochem. Biophys. Res. Commun. 284, 470-477 (2001). | |
| Ohtsuki, T., Watanabe, Y., Takemoto, C., Kawai, G., Ueda, T., Kita, K., Kojima, S., Kaziro, Y., Nyborg, J., and Watanabe, K. An “elongated“ translation elongation factor Tu for truncated tRNAs in nematode mitochondria. J. Biol. Chem. 276, 21571-21577 (2001). | |
| Yamauchi, J., Tsujimoto, G., Kaziro, Y., and Itoh, H. Parallel regulation of mitogen-activated protein kinase kinase (MKK) 3 and 6 (MKK6) in Gq-signaling cascade. J. Biol. Chem. 276, 23362-23372 (2001). | |
| Yamauchi, J., Itoh, H., Shinoura, H., Miyamoto, Y., Tsumaya, K., Hirasawa, A., Kaziro, Y., and Tsujimoto, G. Gaq-dependent activation of mitogen-activated protein kinase kinase 4/c-Jun N-terminal kinase cascade. Biochem. Biophys. Res. Commun. 288, 1087-1094 (2001). | |
| Mizutani, S., Inouye, K., Koide, H., and Kaziro, Y. Involvement of B-Raf in Ras-induced Raf-1 activation. FEBS Lett. 507, 295-298(2001). | |
| <2002年> | |
| Okumura, E., Fukuhara, T., Yoshida, H., Hanada, S., Kozutsumi, R., Mori, M., Tachibana, K., and Kishimoto, T. Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition. Nature Cell Biol. 4, No.2, in press (2002). | |
| Alim, M.A., Hossain, M.S., Arima, K., Takeda, K., Izumiyama, Y., Nakamura, M., Kaji, H., Shinoda, T., Hisanaga, S., and Ueda, K. Tubulin seeds a-synuclein fibril formation. J. Biol. Chem. in press(2002). | |
| Edamatsu, H., Kaziro, Y., and Itoh, H. Differential display of mRNAs regulated by G-protein signaling. Methods Enzymol. 345, 521-529 (2002). | |
| (2)口頭発表 | |
| 1) 国際会議での講演発表 | |
| <1996年> | |
| Kishimoto, T., and Tachibana, K. Regulation of G1/S-phase transition at fertilization in mature starfish eggs. 7th French-Czech-Slovak Conference on “Physiology of Reproduction“ (Liblice, Czech, 1996, 5). | |
| Kishimoto, T. Start and finish in oocyte maturation. 2nd BIO-TIT International Symposium on “Regulation of Cell Cycle and Expression of Cellular Functions“ (K. Nagai and T. Kishimoto) (Yokohama, 1996, 9). | |
| Kishimoto, T. Starfish oocyte maturation and fertilization. 12th International Symposium in Conjunction with Award of the International Prize for Biology “-Biology of Reproduction-“ (M. Hoshi, K. Hoshi, T. Kishimoto, M. Morisawa, M. Takahashi, Y. Nagahama and T. Yahara) (Hayama, 1996, 11). | |
| Kaziro, Y. Korean Biochemical Society (Plenary lecture, Seoul, Korea, 1996, 5). | |
| Kaziro, Y. GTP-binding proteins involved in signal transduction. International Symposium on Proteins and Enzymes at Institute for Basic Sciences, Chungbuk National University (Chungbuk, Korea, 1996, 5). | |
| <1997年> | |
| Kishimoto, T., Ohsumi, K., and Tachibana, K. Repression of S-phase during meiotic cycles in Xenopus and starfish oocytes. EMBO Workshop on “Meiotic Maturation: Signal Transduction Pathways and Checkpoint Controls“ (Cuenca, Spain, 1997, 9). | |
| Kishimoto, T. Downregulation of MAP kinase links egg activation to the entry into S-phase in starfish. Developmental Biology of the Sea Urchin XI (Woods Hole, U.S.A., 1997, 9). | |
| Kishimoto, T. Initial activation of cdc2 kinase at the entry into M-phase. Jacques Monod Conference on “The Cell Cycle“ (Roscoff, France, 1997, 10). | |
| Kishimoto, T. End of meiotic cell cycle: initiation of the first cleavage cycle. International Symposium on “Germ Cell Development and Meiotic Regulation“ (M. Yamamoto, Y. Nagahama, S. Abe, T. Kishimoto and N. Sagata) (Hakone, 1997, 11). | |
| Kishimoto, T. Maturation of starfish oocyte maturation. 13th International Congress of Comparative Endocrinology, Symposia “Historical Development of Comparative Endocrinology in Japan“ (Yokohama, 1997, 11). | |
| Kaziro, Y. Function of GTP-binding proteins in the cellular signaling system. The Third Hamamatsu International Symposium on Biophotonics: Molecular Communication in Cellular Physiology (Hamamatsu, Japan, 1997, 2). | |
| Kaziro, Y. Symposium of FAOBMB (Manila, Philippine, 1997, 12). | |
| <1998年> | |
| Hisanaga, S. Dephosphorylation and phosphorylation of neuronal intermediate filament,neurofilaments. 3rd International Conference on Cellular Regulation by Protein Phosphatases. Hiroshima University School of Medicine (Hiroshima, 1998, 11). | |
| Kaziro, Y. Intracellular signal transduction and function of GTP-binding proteins. Carmen and Severo Ochoa Memorial Lecture 1998 (Madrid, Spain, 1998, 11). | |
| <1999年> | |
| Kishimoto, T. Meiotic cell cycle control. Human Frontier Science Program 10th Anniversary Workshop “Replicon Theory and Cell Division“ (W. Fangman, T. Kishimoto and M. Kohiyama) (Strasbourg, France, 1999, 5). | |
| Kishimoto, T. Meiotic and early embryonic cell cycle control in starfish. UNESCO-ICRO International Training Course on Molecular Aspect of Fertilization and Early Development (Asamushi, 1999. 10). | |
| Hisanaga, S., and Kishimoto, T. Molecular Mechanism of mitotc microtubule-destabilization by phosphorylation of MAP4 with cdc2 kinase. The 42nd NIBB conference. “Tubulin 30 Years Later“, National Institute for Basic Biology (Okazaki, 1999, 2). | |
| Kaziro, Y. A family of GTP-binding proteins: Their function in cellular signaling systems. 99th General Meeting of the American Society for Microbiology (Chicago, USA, 1999, 6). | |
| Kaziro, Y. Riken Symposium (Tokyo, Japan, 1999, 10). | |
| Kaziro, Y. A family of GTP-binding proteins: Their function in cellular signaling systems. 3rd Workshop on “Molecular Biology and Biotechnology“ of the Asssociation of East Asian Research Universities (AEARU) (Plenary lecture, Tokyo, Japan, 1999, 11) | |
| <2000年> | |
| Kishimoto, T. Meiotic cell cycle control by starfish Mos. Jacques Monod Conference on “The Cell Division Cycle“ (Roscoff, France, 2000, 4) | |
| Kishimoto, T. Meiotic and early embryonic cell cycle control in starfish---Greetings from the sea---. Window to the zygote 2000: An advanced course (UNESCO-ICRO) of cell and molecular biology of gametes, fertilization and early embryonic development (Prague, Czech Republic, 2000, 8). | |
| Kishimoto, T. Meiotic cell cycle control in oocytes. International symposium of reproductive biology (incorporating the 9th French-Czech-Slovak Colloquim of reproductive biology9 (Stara Lesna, Slovakia, 2000, 9). | |
| Kishimoto, T. Siganlling pathway leading to the activation of cyclin B/Cdc2 kinase at at meiotic G2/M-phase transition. 4th UK-Japan cell cycle workshop(Cambridge, UK, 2000, 9). | |
| Kishimoto, T. A key linking 1-methyladenine signalling to regulatory components of cyclin B-Cdc2. HFSP group meeting (Woods Hole, USA, 2000,10). | |
| Kishimoto, T., Nishiyama, A., and Tachibana, K. A nonproteolytic function of the proteasome is responsible for the dissociation of the cyclin B-Cdc2 complex at the end of M-phase. International Meeting on “Cellular functions of AAA proteins in search of common molecular basis“ (Kyoto, 2001, 3). | |
| 2) 国際会議でのポスター発表 19件 | |
3) 国内の学会発表
口頭発表とポスター発表の総計 190件 | |
| (3)受賞等 | |
1) 受賞
上代淑人 1999年度 日本学士院賞
2000年 米国科学アカデミー外国人会員 | |
2) 新聞報道
久永真市:いずれもアルツハイマー病脳で蓄積をしていることが見つか
ったp25について、p25へ分解する酵素がカルパインである
ことを見つけたことに関する報道。 | |
平成12年6月1日 毎日新聞、東京新聞、産経新聞、日経新聞、
日本工業新聞、日経産業新聞、化学工業日報 | |
| 平成12年6月5日 日刊工業新聞 | |
| 平成12年6月7日 教育学術 | |
|
