TOP > 巻一覧 > 目次一覧 > 書誌事項 > 成果一覧


平成13年度事業開始
千葉県 「ゲノム情報を基本とした次世代先端技術開発」
  145-150
DNA・抗体マイクロアレイの作製技術開発及びその作製・評価
DNAマイクロアレイ作製技術開発
改良型DNAアレイヤーの開発
抗体アレイにおける固定化方法の実践及び評価
抗体電極チップ及び検出装置の開発
がん関連遺伝子の解析
古閑 比佐志


【2006年までの主な成果】
1 Yamamoto H, Kamegaya E, Takamatsu Y, Imai K, Yamamoto T, Hagino Y, Koga H, Ikeda K, PROLONGED CHANGES IN EXPRESSION OF GENES UNDERLYING METHAMPHETAMINE ABUSE, New Research on Methamphetamine Abuse, NY: Nova Science Publishers, Inc., 2006. (in press).
2 Usui-Aoki K, Kyo M, Kawai M, Murakami M, Imai K, Shimada K, Koga H, Protein and antibody microarrays: clues towards biomarker discovery, Frontiers in Drug Design and Discovery 2, 2006. Pp23-33
3 Koga H, Kyo M, Usui-Aoki K, Inamori K, A chip-based miniaturized format for protein expression profiling: the exploitation of comprehensively produced antibodies. Electrophoresis 27, 2006: 3676-3683
4 Yamamoto H, Imai K, Takamatsu Y, Kamegaya E, Hara Y, Shimada K, Yamamoto T, Shen HW, Hagino Y, Kobayashi H, Ide S, Sora I, Koga H, Ikeda K. Changes in expression of the mouse homologues of KIAA genes after subchronic methamphetamine treatment. Ann N Y Acad Sci. 2004, 1025: 92-101
5 Koga H, Yuasa S, Nagase T, Shimada K, Nagano M, Imai K, Ohara R, Nakajima D, Murakami M, Kawai M, Miki F, Magae J, Inamoto S, Okazaki N, Ohara O. A comprehensive approach for establishment of the platform to analyze functions of KIAA proteins II: public release of inaugural version of InGaP database containing gene/protein expression profiles for 127 mouse KIAA genes/proteins. DNA Res. 2004, 11(4): 293-304
6 Yamamoto H, Imai K, Takamatsu Y, Kamegaya E, Kishida M, Hagino Y, Hara Y, Shimada K, Yamamoto T, Sora I, Koga H, Ikeda K. Methamphetamine modulation of gene expression in the brain: analysis using customized cDNA microarray system with the mouse homologues of KIAA genes. Brain Res Mol Brain Res. 2005, 137(1-2): 40-46.
7 Usui-Aoki K, Shimada K, Nagano M, Kawai M, Koga H. A novel approach to protein expression profiling using antibody microarrays combined with surface plasmon resonance technology. Proteomics. 2005, 5(9): 2396-2401
8 Imai K, Mimori T, Kawai M, Koga H. Microarray Analysis of Host Gene-Expression during Intracellular Nests Formation of Trypanosoma cruzi Amastigotes. Microbiol Immunol. 2005, 49(7): 623-631
9 Imai K, Kawai M, Tada M, Nagase T, Ohara O, Koga H, Temporal change in mKIAA gene expression during the early stage of retinoic acid-induced neurite outgrowth, Gene, 2005, 364: 114-122
10 Kyo M, Usui-Aoki K, Koga H, Label-free detection of proteins in crude cell lysate with antibody arrays by a surface plasmon resonance imaging technique, Anal Chem., 2005, 77: 7115-7121
11 Okazaki N, Imai K, Kikuno RF, Misawa K, Kawai M, Inamoto S, Ohara R, Nagase T, Ohara O, Koga H, Influence of the 3'-UTR-length of mKIAA cDNAs and their Sequence Features to the mRNA Expression Level in the Brain, DNA Res., 2005, 12; 181-189
12 Kai N, Iwase K, Imai K, Nakahira E, Soma M, Ohtsuka S, Yagi T, Kobayashi K, Koga H, Takiguchi M, Yuasa S, Altered gene expression in the amygdaloid subdivision of Fyn-deficient mice as revealed by cDNA array analysis, Brain Research, 2006, 1073-1074; 60-70