 | Nickel Catalyzed Benzene Derivatives Formation from Zirconacyclopentadienes
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| | Hui Wang1), Fu-Yu Tsai1) and Tamotsu Takahashi1) |
| | 1) Catalysis Research Center and Graduate School of Pharmaceutical Science, Hokkaido Univ. |
| | Transition-metal-catalysed or -mediated coupling of three alkynes to give benzene derivatives has been well established in organic synthesis. We have reported benzene formation from zirconacyclopentadienes and third alkyne in the presence of stoichiometric amount of CuCl or NiX2(PPh3)2. Here, we would like to report nickel-catalyzed coupling reaction of zirconacyclopentadienes with two equiv of 1-halo alkyne as shown in eq(1).
To the solution of zirconacyclopentadiene prepared in situ was added the 1-bromo or chloro alkyne and 10 mmol% NiCl2(PPh3)2 at rt for 24h, benzene derivatives were formed in moderate yield. |
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