 | | | | | Abstract: Many important processes in proteins such as folding, protein complex formation, signal transduction or energy transduction take place as large-scale structural changes on ms to s time scales and 10 to 100 nm spatial scales. Development of the method to describe such large-scale movements is essential to understand protein structures and functions. In this project ideas developed in the study of protein folding were exploited to describe these large-scale movements to construct novel computational methods to predict structures and analyze functions. Computational modeling of dynamically moving proteins should give impacts on science and technology of bio-nano machines. |
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